You can also contact us directly to our US landline 61. If you are interested in receiving the benefits of stem cell therapy, you can fill out this contact form and we will give you a call or email you as soon as possible. Motor neurons can be generated in vitro from stem cells of various sources including embryonic stem cells (ESCs), induced pluripotent stem cells (iPS) and neural stem cells (NSCs) The most important therapeutic potential of Stem Cells relies on their ability to regulate inflammation and to empower resident cells to facilitate tissue repair through endogenous stem cell activation or environment modulation. It is fundamental to consider that chronic inflammation plays an important role in ALS. While stem cells are unable to directly replace diseased motor neurons, transplanted stem cells secrete neurotrophic factors and differentiate into supportive cells, such as astrocytes and microglia, generating a neuroprotective milieu that can slow the degeneration of motor neurons. The rate of progression of the forced vital capacity and of the ALS Functional Rating Scale-Revised score in the IT (or IT+IM)–treated patients was reduced (from −5.1% to −1.2%/month percentage predicted forced vital capacity, P < .04 and from −1.2 to 0.6 ALS Functional Rating Scale-Revised points/month, P = .052) during the 6 months following MSC-NTF cell transplantation vs the pretreatment period. Most of the adverse effects were mild and transient, not including any treatment-related serious adverse event. ![]() ![]() Stem cell treatment was found to be safe and well-tolerated over the study follow-up period. Published scientific studies have continuously found that neurotrophic growth factors (NTFs) extend the survival of motor neurons in amyotrophic lateral sclerosis (ALS) and that the combined delivery of these neurotrophic factors has a strong synergistic effect.
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